What is Modafinil?

Modafinil is a prescription medication that is used to increase energy levels and alertness. This is generally prescribed to people who do not get enough sleep. Many users also take Modafinil to increase their ability to study and increase productivity.

Although it is a prescription medication for those that suffer from narcolepsy and sleep apnea, there is also a market online that does not require a prescription. It is sold under the names; Provigil, Alertec, Modiodal, Modapro, and Sun Pharma Modalert.

History of Modafinil

Modafinil was first produced in the 1970s by Michel Jouvet, a French professor. In 1986, it began its use as an experimental treatment for narcolepsy. This condition is when people fall to sleep or faint without any warning throughout the day.

Since it’s first use, it is now being prescribed for a variety of sleep related conditions. Sleep apnea is another common sleep disorder. Also, people who suffer from lack of sleep due to shift work have been prescribed Modafinil.

American and British soldiers have used Modafinil to stay awake for long periods of time. For those that do not get enough sleep, Modafinil tends to help increase their cognitive performance. Some doctors have also reported taking this substance when working an overnight shift.

In Canada and over the Internet, Modafinil is currently being marketed as ‘Alertec.’ It is a less expensive version of Provigil. Various generic brands have been available since the year 2006. However, Cephalon had worked hard to defend this patent. In 2011, Cephalon was sold to Teva.

How to Use Modafinil

Take Modafinil orally with or without a meal. This dose should be taken in the morning or as directed by your doctor. If you are taking Modafinil before shift work, consume it an hour before you begin. Your dose will be based on the condition you have, and your response to Modafinil.

When it comes to Modafinil, sometimes less is more. You should be taking the minimum dose to minimize any side-effects, as well as tolerance. Modafinil tends to work best when taken in a cycle, as sporadic use will increase effectiveness.

If you are using Modafinil short-term, limit yourself to three times a week for example. You can slightly increase your dose if tolerance begins to build. Then, take a week break. If using long-term, alternate weeks. Risk of dependence is extremely low. However, if you have a history of addiction, speak with your doctor regarding this.

Some users have experienced feelings of anxiety when taking Modafinil. These users tends to stack with a supplement that counteracts this side-effect. Taking 500 mg of Phenibut for example will work to eliminate this issue. Using Modafinil in a stack will provide the alertness you desire, so that you can achieve high cognitive abilities.


How Does Modafinil Work?

Modafinil is known to cause stimulation within the peripheral sympathetic system. However, its role in the central nervous system is still not fully understood. It is believed that it targets areas in the anterior hypothalamus. Modafinil also has an affect on dopamine, increasing concentrations of this neurotransmitter. Release of dopamine is dependent on dose, but there is not any sign of Modafinil-induced arousal.

When a user feels more alert, it may be a result of the neurotransmitter anandamide. It is believed to play a role in human sleep patterns. It is also thought to excite the glutamatergic system, reducing the amount of GABA.

When a user takes Modafinil, histamine activity rises. The main component of Modafinil, goes by the same name: ‘Modafinil.’ It is not fully understood how this component works. In a few studies, it was revealed that histamine levels are altered.

One method of action involves orexins, which are brain peptides. When these are activated, dopamine levels rise as well as histamine levels. There are two orexin receptors in the human body. When these systems are defective, symptoms associated with narcolepsy are witnessed. Research is continually being conducted to better understand these processes.

Benefits of Modafinil

For those that suffer from sleep disorders, it can be highly beneficial in allowing increased cognition and wakefulness. It provides these users with a sense of clarity, improving focus. This is especially true for patients suffering from narcolepsy.

Narcolepsy is caused by a dysfunction in wakefulness-promoting peptides. These peptides are known as orexins, which were mentioned above. When taking Modafinil, it is believed that these neurons become activated. This is thought to increase motivation as well.

  • Users have reported an improved mood. Dopamine is believed to play a small role within the method of action, so this could be related.
  • Provides 10-12 hours of wakefulness. This is why Modafinil should be taken in the morning (with the exception of shift work employees).
  • Users become more focused, making them more productive. This is related to the same effect as caffeine, except users do not experience any jitters. The effects also last longer than caffeine.
  • Studies have shown that Modafinil increases and retains cognitive function when users are in a healthy state against factors such as sleep deprivation. More research still needs to be conducted to verify these potential effects.

Since most of the benefits are associated with wakefulness, many students are taking this substance during competitive exams. This has been seen at some of the leading British universities. Consult your doctor about using Modafinil in a stack with more cognitive enhancing supplements.

Possible Side-Effects

When Modafinil is used as directed, it is considered to be safe and and effective. No dangerous side-effects have been reported. However, there have been mild symptoms reported throughout normal use. If you experience these symptoms, speak with your doctor. You should also consult your doctor regarding any allergies you may have.

These mild side-effects include; headache, lack of appetite, nausea, weight loss, nervousness, and hypertension. This is why it is important to discuss details with your doctor prior to your first dose.

If you have any previous health conditions, you need to speak to your doctor before use. Heart conditions for example need to be discussed regarding stimulants. The same holds true for high blood pressure, liver problems, mental health issues, or addiction concerns.

Some medications may interact with Modafinil, increasing side-effects or changing how your medications work. Take a list of your medications into the doctor with you and ask how they will interact with Modafinil. It is better to be safe, knowing that you will not develop any complications.

Recommended Dosage

It is recommended that you take one 200 mg dose per day. You should take your dosage in the morning (unless you’re involved in shift work), as it has long lasting effects. With a total half-life of 15 hours, it is not recommended that you take this substance after midday.

When cycling, start with even lower doses. For example, taking Modafinil three times daily could look like this: Monday take 100 mg, Wednesday take 150 mg, and then Friday can be 200 mg. This will decrease your chances of developing a tolerance.

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