Within the coming years, Coluracetam is expected to gain traction in the brain supplement market. As a racetam compound that’s been derived from Piracetam, Coluracetam was only first registered in 2005. Originally invented and patented in Japan, this supplement was transferred to the company known as BrainCells Inc.

In 2010, trials continued, yielding promising results for treating major depressive disorder as well as general anxiety. Due to its effects, both the medical and nootropic community are showing keen interest. Since this supplement is a compound of racetam, it shares a lot of the same characteristics.

Like other racetams, it works by increasing choline uptake even if neurons are impaired. Due to its involvement in improving visual processing, more medical practitioners are likely to adopt this supplement for optic nerve and retinal injuries. Overall, vision becomes more vivid.

Although distribution is still fairly limited, thousands of Americans have already experimented with Coluracetam and feedback has been positive so far. Let’s explore some of the positive benefits, as well as how this supplement works, the correct dosage, and how to avoid side effects.

What is Coluracetam

Coluracetam, as known as MKC-231 has been classed as a nootropic agent. It’s known to enhance cognitive effects, based on the ways in which it influences choline uptake. Originally developed to treat Alzheimer’s disease, Coluracetam was found to be more effective as a nootropic and is purely marketed as a cognitive enhancer.

It is one of the newer racetam nootropics to reach the market. Since Coluracetam enhances levels of choline in the brain and body, it increases the production of acetylcholine. Without acetylcholine, we wouldn’t be able to remember the simplest of facts or move our muscles. It’s been reported that Coluracetam not only increases acetylcholine levels but also speeds up its flow.


The Benefits of Coluracetam

Coluracetam offers many benefits, however, the most exciting is its ability to improve long-term memory within memory-impaired individuals. Humans have tested Coluracetam, but the majority of testing has taken place with animals. When tested on rats using a commonly used maze test, memory improved. The effects continued, improving memory after this supplement had left their system. This shows that Coluracetam may have potentially long-term effects.

As mentioned, when tested within the Phase 2A trails, Coluracetam showed that it was effective in treating both depression and anxiety. Some patients had not experienced any positive effects in the past by taking anti-depressants, yet experienced the benefits associated with Coluracetam. While assessing depression levels, 36 percent of participants experienced significant improvements.

Many other users also expressed the way in which this supplement creates feelings of contentment and deep peace. When used with other racetams, Coluracetam produces nootropic-like effects. Not only is memory improved, but decision making, along with a number of other cognitive effects increase. This has been shown through a number of studies, reporting that Coluracetam enhances the overall speed of cognition and concentration levels.

Coluracetam has also been shown to have stimulant effects. If you suffer from dreariness in the morning, taking this nootropic could help increase energy levels so that you’re able to approach the day with improved motivation. This will help you complete tasks, maintaining an edge in the workplace.

How Does Coluracetam Work?

Coluracetam mainly works by enhancing choline uptake, meaning it enhances the overall level and efficiency of choline throughout the body. It’s important to note that choline is a precursor to the neurotransmitter acetylcholine. This hormone plays a crucial role in terms of memory, learning, as well as other cognitive effects.

Coluracetam may also work based on AMPA receptors which influence glutamate in the brain. When your neurons make new connections, this is referred to as synaptic plasticity. Of all your neurotransmitters and brain hormones, glutamate is the most central within this process. As these new connections are formed, your brain is essentially making new memories.

How Much Coluracetam Should You Take?

There’s not a recommended medical dosage just yet, as this supplement is still considered more of a novelty supplement. Based on studies, however, an approximate 200 mg dose daily appears to be the most effective for the average person. Like any supplement or nootropic, this dosage may fluctuate based on your needs and what you’re taking the supplement for.

For those that suffer from major depressive disorder, a dose of 100 mg three times daily appears to be the most effective. For those that suffer from general anxiety disorder, a similar dose is recommended. If you have already experimented with some of the stronger racetams, you may find that 200 mg daily is ideal. With that being said, if you lack experience, start with as little as 20 mg in order to experience the positive effects. Over time, you can slowly increase your dosage.

Do I Need to Be Concerned with Potential Side Effects?

Due to the limited history of this supplement, there isn’t a lot of definitive information regarding potential toxicity levels. As of now, this supplement appears to be safe based on the way it works within the body and brain. It’s effects and structure are similar to various popular, safe, and effective racetams.

Thus far, BrainCells has not observed any negative side effects when Coluracetam was administered in 80 mg doses, three times daily. Based on the side effects associated with other racetams, you may encounter headaches when taking this supplement.

This side effect can generally be counteracted by stacking a racetam with Alpha GPC, CDP Choline, or Centrophenoxine. When taken together, headaches are typically no longer experienced for most people.