How Do Nootropics Work?

How Do Nootropics Work?

People are naturally interested in how nootropics actually work. Although one simplified answer would be ideal, this is not the case. There are various different nootropics, as well as methods involved. Due to these variations, this question is complicated to answer. In order to better understand how nootropics work, please feel free to first read the article regarding the types of nootropics that are available. There is no single answer to describe how nootropics work, but they do achieve their positive effects by changing the supply of various neurotransmitters, hormones, or enzymes. Improved plasticity also plays a role, as this determines how well synapses connect and communicate.

The Human Brain

Although we have learned so much, there are still areas that are extremely limited in terms of understanding the human brain. It is such a complex organ, with so much left to discover. As an adult, the average brain has approximately 100 billion neurons, creating trillions of connections and interactions. With that being said, we have made incredible advances over the years. We have learned so much, which is why we have a thorough understanding of these ‘smart drugs.’ When it comes to nootropics, it depends which type you use. Nootropics have a positive effect on the brain, but the type of nootropic will dictate the response. Some will enhance memory, some will impact mood, while others will enhance focus and attention.

As mentioned throughout the site, Piracetam was the first nootropic that was developed. This nootropic optimizes transmission of neurons into the corpus callosum, which is the area that connects the two hemispheres within the brain. It also increases the levels of acetylcholine, which is a neurotransmitter vital for brain function. Other nootropic substances affect hormones, while others affect neurotransmitters (much like antidepressants do). For the most part, they work with your natural brain chemistry. They tend to encourage neurotransmitter production or inhibit its re-uptake. This yields positive effects on mood and cognition.

NeuroTransmitters and Synaptic Receptors

If you’re unfamiliar with neurotransmitters, they are chemicals that transmit signals from one neuron to another neuron. According to the messages that are received, neurotransmitters bind to specific receptor sites. Together, these receptors and neurotransmitters create a system. Basically, nootropics target these ‘systems’ and enhance their efficiency in relation to cognitive abilities and function. Below are some of these systems, providing a more thorough explanation.

Acetylcholine in Regards to the Cholinergic System

The Cholinergic system is reliant on Acetylcholine, which is a neurotransmitter that affects cognitive function. It has been found that this neurotransmitter plays a role in memory, learning, focus, and decision-making. Therefore, cholinergics are any supplement that increases the levels of this neurotransmitters. We normally obtain Acetylcholine from a choline-rich diet. It is found in the highest amounts within eggs, various animal organs (e.g. liver, kidneys brain), various species of fish, whey, and various other ingredients. Although it is technically possible to consume enough choline through one’s diet, you would need to consume around five or more eggs daily. Many people are actually deficient in choline.

There are many supplements that provide choline, which tend to be stacked with supplements from the racetam class. Without enough choline, acetylcholine can not be synthesized. It is essential for proper brain function, which is why so many people use it in a stack. Alpha GPC and Centrophenoxine are both great options. Racetams work similar to cholinergics, but instead of increasing acetylcholine levels, they improve the sensitivity of acetylcholine receptors. This means that they communicate more effectively, resulting in higher brain function. An acetylcholine precursor is generally taken with racetam to eliminate the risk of headaches, as this is the most common side-effect.

Glutamate in Regards to the Glutamatergic System

Glutamate is the most abundant excitatory neurotransmitter within our nervous system. It is vital in terms of overall brain health, as well as aspects of memory and learning. There needs to be a proper balance of glutamate levels in the brain. It is not as commonly affected as acetylcholine or dopamine, but a few nootropics do rely on the glutamate system. Aniracetam for instance reduces sensitivity to glutamate, leading to an increase in brain activity. Cognitive functioning is then improved.

Dopamine and Serotonin in Regards to the Dopaminergic and Serotonergic System

Dopamine and serotonin are both neurotransmitters that play a huge role in nootropic use. They both have a large effect on how we feel in terms of our mood and well-being, as well as feeling motivated. They have been seen to positively affect memory and our ability to focus as well. Not all nootropics use these systems, and they’re not generally the primary method of action. However, these systems do play a role in the overall effect of nootropics. Those that directly affect serotonin, tend to be supplements with more mood enhancing abilities. These are generally stacked with supplements that increase cognitive functioning. Once dopamine is stimulated, you will feel higher levels of brain energy, while improving cognition. Sulbutiamine is an example of a supplement that has this effect. Any mood enhancing nootropics will affect dopamine and/or serotonin in some way.

Blood and Oxygen Flow to the Brain

When taking some nootropic supplements, blood flow and oxygen uptake tend to be improved. As well, there is an increase in glucose metabolism. When this occurs, overall brain energy increases. This is due to an increase in nutrients and oxygen, promoting feelings of alertness and focus. Our natural energy reserves our continually being depleted. Oxygen and glucose are our core sources of energy within the brain, and are essential for proper functioning. When this supply is increased, you will feel less fatigued and your cognition will improve. Motivation is also generally affected, providing a more balanced sense of well-being. Pramiracetam is extremely effective at boosting energy levels, increasing focus. Piracetam also improves blood flow and glucose metabolism, providing the brain with what it needs.

Brain Plasticity

Brain plasticity is crucial in terms of learning and how the brain changes as a result of experience. Nootropics have an affect on our brain plasticity, altering the synapses in the brain. Synapses are what send signals, essentially communicating. Our memories for instance, involved the complexity of synapses. How well we can recall memories and information, depend on well these synapses are linked. When plasticity is improved, it makes it easier for these synapses to connect and communicate. Communication is also improved between the two brain hemispheres when certain nootropics are taken. It is believed that new synapses are built, essentially connecting the two hemispheres. Since increased learning and memory are a benefit experienced by nootropics, it’s no surprise that brain plasticity plays a role.

Buy Nootropics Stacks Online

If you want to buy nootropics online, there’s never been a better time. Thanks to the internet, it’s super simple to order your nootropics stacks and have them delivered to your home. On top of that, it’s also completely safe. And when you factor in the gas it takes to drive around town to try to get them all, it can also be less expensive to purchase nootropics online. The only way you’re really going to be able to tell if they will work for you or not is to buy them and try them for a month at least. Ordering a one month supply of nootropics doesn’t take a lot of time at all.