Pregnenolone is known as a steroidal hormone, offering powerful nootropic effects. It is currently used to enhance focus, improve mood, and boost energy levels. In more recent studies, Pregnenolone has been shown to improve memory, information processing, and comprehension. One researcher from the Geriatric Research Education and Clinical Center, Pregnenolone is the most potent memory enhancer reported to date.

Although a supplement, Pregnenolone is actually one of the most critical hormones within the human body. It is used to produce some of the most chemicals and hormones within the human body, such as androgens and estrogens. Pregnenolone is what’s referred to as a pro-hormone, meaning it leads to an increased production, development, and synthesis of vital hormones and chemicals.

Naturally synthesized from cholesterol, Pregnenolone is produced in the adrenal glands, but can also be synthesized in the liver, brain, skin, eye, ovaries, and testicles. Although Pregnenolone has some powerful effects, also being a precursor to cortisol, estrogen, progesterone, and testosterone, it produces few significant side effects.

The Effects of Pregnenolone

As mentioned, Pregnenolone is a natural hormone that is produced in the human body. With that being said, there are a lot of factors that can interfere with the natural production of this hormone. The first key factor is age. As we grow older, our levels of Pregnenolone decrease as production declines. For this reason, many benefit from taking a dietary supplement to help increase levels to a more normal range.

When taken orally, Pregnenolone passes through the blood-brain barrier, entering your central nervous system. Pregnenolone works through a number of biological and chemical processes. Some refer to it as the mother hormone, due to its role in producing other hormones and chemicals. It’s also known to balance hormone levels and works equally well in both men and women.

It’s also believed to influence the transmission of messages from one neuron to another. More specifically, Pregnenolone influences NMDA receptors which are involved in cognitive functioning. These receptors generally respond to Glutamate, aiding in the formation of new synapses. It’s believed that taking Pregnenolone, helps to improve memory formation, leading to an increasing ability to learn.


Key Benefits of Pregnenolone

When taking this supplement, users experience a wide range of benefits. Firstly, Pregnenolone may produce anti-aging effects, slowing down premature aging. Not only physically, but neurologically as well. It’s been shown to protect and repair the myelin sheath that surrounds nerve cells.

When taking this supplement in clinical studies, individuals experienced reduced arthritis and osteoarthritis symptoms. Reduced levels of cortisol have also been reported, especially when levels rose to excessive concentrations. In turn, this boosts immunity, reduces fatigue, and helps boost energy levels. Poor mood is also positively impacted, restoring balance. When taking Pregnenolone, users experience a more positive mental outlook.

This is why Pregnenolone is effective for treating symptoms of depression, mood disorders, and pain associated with fibromyalgia. It’s also been shown to reduce feelings of stress and anxiety while speeding up the repair of damaged nerves. For those who suffer from sleeping disorders, Pregnenolone has been shown to reduce symptoms of insomnia and other chronic sleep conditions, as well as degenerative conditions like lupus and diabetes.

In terms of cognition, Pregnenolone has been shown to boost motivation, memory, and learning capacity. When studied, users also experienced a heightened sense of well-being and alertness. For those that were most stressed to begin with, they showed the greatest benefits in terms of productivity.

What are the Side Effects?

Before taking a new supplement, you should be aware of the potential side effects. The side effects associated with this supplement are directly linked to the dosages users take. Based on this, users should not take Pregnenolone for extended periods of time.

There haven’t been an excessive amount of studies done on this supplement so users are advised to be cautious. When taking high doses over long periods of time, this is when adverse effects tend to surface, such as:

Oily skin and increased acne: Due to Pregnenolone’s effect on androgens, this is likely the cause of this effect. Although severe acne isn’t long-term, it’s undesirable and could take weeks to clear up.

Increased aggression and anxiety: When taken in low doses, Pregnenolone helps to reduce stress and anxiety. When taken at high doses, however, users can become angry, irritable, and anxious.

Headaches and hair loss: When taken for several weeks, users often experience headaches. Since Pregnenolone converts into DHEA, then testosterone and DHT, this may increase balding for those who are predisposed.

Sleeping issues: At low doses, Pregnenolone can help sleep. When taken at high doses, the opposite effect can occur. Users have experienced both insomnia and night sweats.

Heart palpitations: If you’re taking even a low dose of 5 mg every day, you increase your risk of heart rhythm disturbance. This is different across users, as not everyone experiences the same arrhythmia effects.

Effects of withdrawal: If taken for a prolonged period, withdrawal can be a difficult step to endure. Symptoms may heighten, such as anxiety, nervousness, and restlessness. Some users have reported that they become paranoid and fatigued. To safely withdraw, reduce your dose by 10 mg a day until you’re off it and no longer experience symptoms of withdrawal.

What is a Safe Dose?

Dosing is especially important when taking Pregnenolone. The typical dose ranges from 5 to 20 mg per day. This is often broken down into two administrations. When taken in small doses for short periods of time, it’s said to be extremely safe. Start with a small dose of 5 mg a day, only two to three days a week. This dosing schedule should not be prolonged, as side effects are more likely to surface. The key with hormones is taking low doses, over short periods of time, taking frequent breaks.