What is a Cholinergic?

Cholinergics is any drug or supplement that has an effect on the neurotransmitter acetylcholine. This means that it can either mimic, enhance, or inhibit it. Acetylcholine is essential regarding brain function and is responsible for memory, focus, stress and more. Basically, cholinergic refers to an acetylcholine producing system.

These supplements can create higher levels of concentration, perception, recall, and overall cognitive function. When you hear of degenerative memory disorders such as Alzheimer’s, these issues with memory are linked to low levels of acetylcholine.

There are no supplements that will provide pure acetylcholine. However, various cholinergic supplements allow you to raise acetylcholine levels. Some of the best cholinergic supplements are; Citicoline, Alpha-GPC, Acetyl L-Carnitine, and Centrophenoxine.

What is Acetylcholine?

Before you can understand the cholinergic class of nootropics, you need to understand acetylcholine. It was the first neurotransmitter discovered, and is essential for cognitive functioning. It aids in memory, learning, and decision-making.

The cholinergic system is vital when producing this neurotransmitter. If there is damage to this system, you can either experience a decrease in acetylcholine or your receptors will not work efficiently. This is thought to cause Alzheimer’s disease and other degenerative cognitive disorders.

The Role of Choline in Cognitive Enhancement

Choline is needed in order to synthesize acetylcholine. It is found in various foods in our diet, yet majority of people are still deficient. If you take a nootropic like Piracetam for instance, it will target your acetylcholine levels. If your levels are too low, this can create undesirable effects, such as headaches.

When you take choline supplements, you’re basically feeding this system. You’re providing the materials needed in order to produce this vital neurotransmitter. This is why choline is often taken in a stack with racetams.

Cholinergics can work in a number of ways:

  • They work as an agonist, allowing cholinergic receptors to be stimulated
  • They work as an antagonist, inhibiting the actions of the cholinergic receptor
  • Block and stimulate receptors found on the autonomic ganglia
  • Inhibit metabolism of acetylcholine, increasing levels and prolonging the effects

Technically, cholinergic nootropics only involve supplements that produce acetylcholine. However, anything involving acetylcholine is classed as a cholinergic. There are acetylcholine precursors, inhibitors, and allosteric modulators.

Alpha GPC and Citicoline are both acetylcholine precursors, which are considered to be true cholinergic nootropics. They aid in the production of acetylcholine. These two nootropics create higher levels of this vital neurotransmitter. Although they affect acetylcholine levels, they also yield nootropic effects.

Types of Chonlinergics

1. Alpha GPC

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This nootropic is mainly used as an acetylcholine supplement, generally taken in a stack with racetams. This supplement breaks down into acetylcholine, making it highly beneficial. When taken on its own, it improves learning abilities, memory function, and reduces stress.

2. Centrophenoxine

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Less is known regarding this supplement in terms of its mechanism of action. However, it is known that it increases levels of acetylcholine when taken. This is a great supplement to be stacked with Aniracetam, Oxiracetam, and Piracetam.

It is known to improve functioning in Alzheimer’s and dementia patient. It is also a powerful antioxidant, which makes it great when attempting to combat brain aging.

3. Citicoline


Citicoline is a popular choline supplement, as it is sold in over 70 countries. Once Citicoline crosses the blood-brain barrier, it is found in two components; choline and cytidine. When the levels of choline are increased, acetylcholine is increased. This allows for improved cognitive functioning.

Citicoline improves users memory and learning abilities. It also helps to increase brain energy levels and brain metabolism improves. This supplement is often taken in a stack, diminishing headaches caused by some racetams.

Stacks That Target Cholinergic Receptors

When taking nootropics in a stack, most users want to boost cognitive function. The most common stack for the cholinergic system is racetams. The most common racetams are; Piracetam, Oxiracetam, Pramiracetam, and Aniracetam.

The choline sources such as Alpha GPC and Citicoline work well with racetams because the provide the material needed to produce acetylcholine. Then, racetams work to stimulate the acetylcholine that has been produced. When taken together, the result is increased memory, focus, and learning ability.

Buy Cholinergics Online Safely

If you want to order Cholinergics as part of a nootropics stack online, it’s actually quite easy to do this. Affecting the neurotransmitter acetylcholine by buying Cholinergics supplements online is safe, easy, and very convenient. Why drive all over town trying to find a pharmacy or health food store that carries the right brand, strength and quality of Cholinergics. We’ve made it easy for you by providing a place to get this smart drug online so you can try it for yourself.